In 1954, the Alpha Omega leadership in the U.S. decided to establish Chapter No. 20 in Israel. Jacob Levin-Epstein was appointed as the first regent, founder, and organizer of the fraternity in the country.
On July 29, 1954, during a visit to Israel by the international president, Louis J. Galin, a reception was held for him at the Tourism Club in Talbiya, where members of the Jerusalem chapter were inducted.
The 14 members of the Jerusalem chapter present were: Regent Jacob Levin-Epstein, Shmuel Levin-Epstein (President of the Jerusalem branch), and members Chaim Barent, Moshe Glazman, Alexander Grossman, Binyamin Weissberg, Jacob Yardeni, Y. Lapidot, Yitzhak Michman, Fritz Fried, Moshe Rabinowitz, Kurt Rosenzweig, Rudy Rudberg, and Eino Shaki.
On August 1, 1954, the Haifa chapter was established, inducting nine members: H. Braunschweiger, Kurt Dankwort, David Gutman, H. Lachman, M. Chizik, Georg Winternitz, Y. Yanai (from Zichron Yaakov), K. Zucker, and A. Packel.
On August 3, 1954, a major event took place at the Zionist House of America in Tel Aviv, where the following members were inducted: B. Becker, H. Berger, M. Binur, Chaim Idels, G. Grossman, L. Hirsch, Moshe Mishori, H. Niederland, M. Salpeter, Aryeh Sarnat, Yitzhak Zifert, Avraham Zusman, Sh. Tajer, M. Weiner, Z. Zeidner (this list is incomplete).
Soon after, with the establishment of chapters in Israel’s three major cities, a student group also began organizing at the School of Dentistry in Jerusalem to provide a continuous stream of new members for the fraternity. The students were organized under the Alpha Sigma chapter. In August 1959, during a visit by the fraternity’s U.S. president, David Dean, to celebrate the graduation of the school’s first class, the student members were inducted. The first president of Alpha Sigma was Shmuel Perlmutter, and the initial members included Jacob Ehrlich, Israel Giladi, Miki Helfet, Ehud Melberger, Zvika Messner, Chaim Sarnat, Nathan Portuguese, and Musick Kaplan.